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What happens if I miss a dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
Advice to Patients
Advise the patient to read the FDA-approved patient labeling.1
Risk of Osteosarcoma
Advise patients that abaloparatide caused a dose-dependent increase in the incidence of osteosarcoma in male and female rats and that it is unknown whether abaloparatide will cause osteosarcoma in humans.
Instruct patients to promptly report signs and symptoms of possible osteosarcoma such as persistent localized pain or occurrence of a new soft tissue mass that is tender to palpation.1
Advise patients that abaloparatide may cause hypercalcemia, and discuss the symptoms of hypercalcemia (e.g., nausea, vomiting, constipation, lethargy, muscle weakness).1
Instruct patients to promptly report signs and symptoms of hypercalcemia. 1
Advise patients to sit or lie down if they feel lightheaded or have palpitations after the injection until their symptoms resolve. If these symptoms persist or worsen, advise patients to consult their healthcare provider before continuing treatment.
Use of Abaloparatide Pen
Instruct patients and caregivers who administer abaloparatide on how to properly use the abaloparatide pen and to follow sharps disposal recommendations. Advise patients not to share their abaloparatide pen or needles with other patients and not to transfer the contents of the pen to a syringe.
Advise patients that each abaloparatide pen can be used for up to 30 days, and after the 30-day use period to discard the abaloparatide pen, even if it still contains unused solution.1
How is this medicine (Abaloparatide) best taken?
Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as a shot into the fatty part of the skin in the belly area.
- If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
- Follow how to use as you have been told by the doctor or read the package insert.
- Do not use if the solution is cloudy, leaking, or has particles.
- Do not use if solution changes color.
- Move the site where you give the shot with each shot.
- Do not give into skin within 2 inches of the belly button.
- You may need to use abaloparatide where you can sit or lie down right away if you get dizzy or feel like passing out. Talk with your doctor.
- Take this medicine at the same time of day.
- Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it on the same day you missed the dose.
- If you do not think about the missed dose until the next day, skip the missed dose and go back to your normal time.
- Do not take more than 1 dose of abaloparatide in the same day.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of high calcium levels like weakness, confusion, feeling tired, headache, upset stomach and throwing up, hard stools (constipation), or bone pain.
- Very bad dizziness or passing out.
- A fast heartbeat.
- A heartbeat that does not feel normal.
- Very upset stomach or throwing up.
- Back pain, belly pain, or blood in the urine. May be signs of a kidney stone.
- Pain when passing urine.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution Pen-injector, Subcutaneous:
Tymlos: 3120 mcg/1.56 mL (1.56 mL) [contains phenol]
There are no contraindications listed in the manufacturer's labeling.
There are no known significant interactions.
Abaloparatide Brand Names
Abaloparatide may be found in some form under the following brand names:
For the Consumer
Applies to abaloparatide: subcutaneous solution pen-injector
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Other drugs may interact with abaloparatide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.