Name: Abilify Discmelt
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Before Using Abilify Discmelt
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of aripiprazole in children younger than 13 years of age with schizophrenia and in children younger than 10 years of age with bipolar disorder. Safety and efficacy have not been established.
Aripiprazole is not approved for use in children or teenagers with major depression.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of aripiprazole in children 6 to 17 years of age with autistic disorder.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aripiprazole in elderly patients who have schizophrenia, depression, or bipolar disorder. This medicine should not be used to treat behavioral problems in elderly patients who have dementia or Alzheimer disease.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Arsenic Trioxide
- Morphine Sulfate Liposome
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- St John's Wort
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
- Grapefruit Juice
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Alcohol abuse, history of or
- Depression or
- Diabetes, or family history of or
- Drug abuse or dependence, history of or
- Hyperglycemia (high blood sugar) or
- Neuroleptic malignant syndrome (NMS), history of or
- Neutropenia (low white blood cells) or
- Seizures, history of—Use with caution. May make these conditions worse.
- Blood vessel disease or
- Dehydration or
- Heart attack or stroke, history of or
- Heart disease or
- Heart failure or
- Heart rhythm problems or
- Hypotension (low blood pressure) or
- Hypovolemia (decrease in blood volume) or
- Ischemic heart disease, history of or
- Trouble with swallowing—Use with caution. May cause side effects to become worse.
- Phenylketonuria (PKU)—The orally disintegrating tablet contains phenylalanine, which can make this condition worse.
How is this medicine (Abilify Discmelt) best taken?
Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food.
- Do not push the tablet out of the foil when opening. Use dry hands to take it from the foil. Place on your tongue and let it melt. Water is not needed. Do not swallow it whole. Do not chew, break, or crush it.
- Drink lots of noncaffeine liquids every day unless told to drink less liquid by your doctor.
- To gain the most benefit, do not miss doses.
- Keep taking Abilify Discmelt as you have been told by your doctor or other health care provider, even if you feel well.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
Abilify Discmelt Interactions
Tell your doctor about all the medicines you take including prescription and nonprescription medications, vitamins, and herbal supplements. Especially tell your doctor if you take:
- antidepressants (mood elevators)
- antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral)
- bupropion (Wellbutrin)
- carbamazepine (Tegretol)
- clarithromycin (Biaxin)
- fluoxetine (Prozac, Sarafem)
- HIV protease inhibitors such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Invirase)
- ipratropium (Atrovent)
- medications for anxiety, high blood pressure, irritable bowel syndrome, mental illness, motion sickness, Parkinson's disease, seizures, ulcers, or urinary problems
- nefazodone (Serzone)
- paroxetine (Paxil, Pexeva)
- quinidine (Cardioquine, Quinact, Duraquin)
- rifampin (Rifadin, Rimactane)
- sleeping pills
- telithromycin (Ketek)
This is not a complete list of Abilify Discmelt drug interactions. Ask your doctor or pharmacist for more information.
Abilify Discmelt and Lactation
Tell your doctor if you are breastfeeding or plan to breastfeed.
Abilify Discmelt has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from Abilify Discmelt, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.
More frequent side effects include: dizziness, drowsiness, lethargy, sedation, urinary incontinence, and salivation. See below for a comprehensive list of adverse effects.
Usual Pediatric Dose for Tourette's Syndrome
Age: 6 to 18 years:
-For patients weighing less than 50 kg:
Initial Dose: 2 mg orally once a day
After 2 days: Titrate to recommended dose of 5 mg orally once a day; in patients who do not achieve optimal control of tics; may increase dose to 10 mg once a day; dose adjustments should occur gradually at intervals of no less than 1 week
Maximum Dose: 10 mg orally once a day
-For patients weighing 50 kg or more:
Initial Dose: 2 mg orally once a day
After 2 days: Titrate to 5 mg orally once a day
On day 8: Titrate to recommended dose of 10 mg orally once a day; in patients who do not achieve optimal control of tics; may increase dose in increments of 5 mg per day at intervals of no less than 1 week
Maximum Dose: 20 mg orally once a day
Comments: Periodically assess patients to determine continued need for maintenance treatment.
-The oral solution and oral tablets can be substituted on a mg-per-mg basis up to the 25 mg dose level.
-Dosage adjustments are recommended in patients who are known CYP450 2D6 poor metabolizers and taking concomitant CYP450 inhibitors or inducers; see dosage adjustment section for specific adjustments.
Use: Treatment of Tourette's disorder
Abilify Discmelt is not approved for use in psychotic conditions related to dementia. This medicine may increase the risk of death in older adults with dementia-related conditions.
Some young people have thoughts about suicide when taking medicine for a major depressive disorder and other psychiatric disorders. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.