Name: Accuretic

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What other drugs will affect Accuretic (hydrochlorothiazide and quinapril)?

Other drugs may interact with hydrochlorothiazide and quinapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take Accuretic or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Accuretic. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Review Date: October 4, 2017


Accuretic is contraindicated in patients who are hypersensitive to quinapril or hydrochlorothiazide and in patients with a history of angioedema related to previous treatment with an ACE inhibitor.

Accuretic is contraindicated in combination with a neprilysin inhibitor (e.g., sacubitril). Do not administer Accuretic within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor (see WARNINGS and PRECAUTIONS).

Because of the hydrochlorothiazide components, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs.

Do not co-administer Accuretic with aliskiren:

  • in patients with diabetes.

PRINCIPAL DISPLAY PANEL - 20 mg/12.5 mg Tablet Bottle Label


NDC 0071-0220-23

(quinapril HCl/

20 mg/12.5 mg*

90 Tablets
Rx only

Accuretic Precautions

Serious side effects have been reported with Accuretic or its ingredients including the following:

  • Allergic reactions. Tell your healthcare provider right away if you have some or all of the following symptoms:
    • swelling of the face, limbs, lips, tongue, throat
    • difficulty breathing
    • stomach (abdominal) pain (intestinal angioedema) with or without nausea or vomiting
  • Low blood pressure.
  • Lowered white blood cell count (neutropenia/agranulocytosis) increasing the risk of infections
  • Harm to an unborn baby (fetal toxicity). Do not take Lotensin HCT if you are pregnant or will become pregnant.
  • Liver damage
  • An autoimmune disease in which the body's immune system mistakenly attacks healthy tissue (systemic lupus erythematosus)
  • A condition in which close objects appear clearly, but far ones don't (myopia) or a buildup of pressure in the eye that can cause blindness (glaucoma). Tell your healthcare provider right away if you experience  visual changes or eye pain.
  • Imbalances in the levels of salts and fluids in your body (electrolyte and fluid imbalance). Tell your healthcare provider right away if you have some or all of the following symptoms:
    • dry mouth
    • thirst
    • weakness
    • drowsiness
    • restlessness
    • muscle pains or cramps
    • low blood pressure
    • low output of urine
    • fast heart rate
    • nausea
    • vomiting

Accuretic can also cause tiredness (fatigue) and dizziness. Do not drive or operate heavy machinery until you know how Accuretic affects you. 

Do not take Accuretic if you:

  • are allergic to Accuretic or to any of its ingredients or to other sulfonamide-derived drugs
  • kidneys are unable to produce urine (anuric)
  • history of a type of swelling that affects deeper layers of your skin, often around your eyes and lips (angioedema) with other ACE inhibitors
  • are diabetic and also using aliskiren (Tekturna)

Accuretic Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Accuretic, salt substitutes containing potassium should be avoided. 

Accuretic and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Accuretic falls into category D. When pregnancy is detected, discontinue Accuretic as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the unborn baby.

For the Consumer

Applies to hydrochlorothiazide / quinapril: oral tablet

Along with its needed effects, hydrochlorothiazide / quinapril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / quinapril:

Less common
  • Cough producing mucus
  • diarrhea
  • difficulty breathing
  • tightness in the chest
  • Blistering, peeling, loosening of skin
  • blurred vision
  • confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • increase in heart rate
  • increased sensitivity of skin to sunlight
  • irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • rapid breathing
  • seizures
  • sunken eyes
  • sweating
  • thirst
  • trembling
  • unusual tiredness or weakness
  • weakness and heaviness of the legs
  • wrinkled skin
Incidence not known
  • Shock
  • speech problems
  • swelling of the hands, ankles, or feet
  • unusual bleeding or bruising

Some side effects of hydrochlorothiazide / quinapril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Headache
Less common
  • Back pain
  • coughing
  • lack or loss of strength
  • sleepiness or unusual drowsiness
  • trouble sleeping
  • Change in vision
  • constipation
  • discouragement
  • feeling sad or empty
  • general feeling of discomfort or illness
  • impaired vision
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • trouble concentrating