Acetaminophen, caffeine, and dihydrocodeine

Name: Acetaminophen, caffeine, and dihydrocodeine

What is acetaminophen, caffeine, and dihydrocodeine?

Acetaminophen is a pain reliever that increases the effects of dihydrocodeine.

Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.

Dihydrocodeine is an opioid pain medication. An opioid is sometimes called a narcotic.

Acetaminophen, caffeine, and dihydrocodeine is a combination medicine used to relieve moderate to severe pain.

Acetaminophen, caffeine, and dihydrocodeine may also be used for purposes not listed in this medication guide.

Acetaminophen, caffeine, and dihydrocodeine dosing information

Usual Adult Dose for Pain:

Initial dose: 2 capsules orally every 4 hours as needed
Maximum dose: 5 doses or 10 capsules in 24 hours; no more than 2 capsules should be taken within any 4-hour period.

-Individualize therapy taking into account patients pain severity, prior analgesic treatment experiences, and risk factors for addiction, abuse, and misuse.

Use: For the management of moderate to moderately severe pain that is severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Commonly used brand name(s)

In the U.S.

  • Panlor-DC
  • Panlor-SS
  • Trezix
  • Zerlor

Available Dosage Forms:

  • Capsule
  • Tablet

Therapeutic Class: Opioid/Acetaminophen Combination

Chemical Class: Methylxanthine

Use Labeled Indications

Pain management: Management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Limitations of use: Reserve for use in patients for whom alternative treatment options (eg, nonopioid analgesics) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.

Dosing Geriatric

Refer to adult dosing. Initiate therapy at low end of dosing range and use caution.

Adverse Reactions

Frequency not defined. Most common reactions with this combination include:

Central nervous system: Dizziness, drowsiness, sedation

Dermatologic: Dermatological reaction, pruritus

Gastrointestinal: Constipation, nausea, vomiting

Postmarketing and/or case reports (Limited to important or life-threatening): Hypogonadism (Brennan, 2013; Debono, 2011)