Acetaminophen, dextromethorphan, guaifenesin, and pseudoephedrine

Name: Acetaminophen, dextromethorphan, guaifenesin, and pseudoephedrine

What should I discuss with my healthcare provider before taking this medicine?

You should not use this medication if you are allergic to acetaminophen, dextromethorphan, guaifenesin, or pseudoephedrine.

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially:

  • liver disease, alcoholism, or if you drink more than 3 alcoholic beverages per day;

  • high blood pressure, heart disease, coronary artery disease, or recent heart attack;

  • diabetes;

  • glaucoma;

  • epilepsy or other seizure disorder;

  • enlarged prostate or urination problems;

  • cough with mucus, or cough caused by emphysema or chronic bronchitis;

  • pheochromocytoma (an adrenal gland tumor); or

  • overactive thyroid.

It is not known whether acetaminophen, dextromethorphan, guaifenesin, and pseudoephedrine will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant.

This medication may pass into breast milk and may harm a nursing baby. Decongestants may also slow breast milk production. Do not use this medicine without your doctor's advice if you are breast-feeding a baby.

Artificially sweetened liquid medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU).

What should I avoid while taking this medicine?

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Avoid drinking alcohol. It may increase your risk of liver damage while you are taking acetaminophen.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What other drugs will affect this medicine?

Other drugs may interact with acetaminophen, dextromethorphan, guaifenesin, and pseudoephedrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Feeling nervous and excitable.
  • Not able to sleep.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Some side effects of acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Usual Adult Dose for Cough and Nasal Congestion

Acetaminophen/dextromethorphan/guaifenesin/PSE 500 mg-20 mg-400 mg-60 mg oral tablet:
1 tablet orally every 4 to 6 hours not to exceed 4 tablets daily.

Dialysis

Data not available

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