Acetic Acid

Name: Acetic Acid

Introduction

Sterile, nonpyrogenic solution with antimicrobial and acidifying effects that is used for urologic irrigation.1 2 3 4

Acetic Acid Pharmacokinetics

Absorption

Bioavailability

Systemic absorption unlikely unless open lesions of the bladder mucosa are present.2 4 (See Appropriate Use of Acetic Acid 0.25% Irrigating Solution under Cautions.)

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Acetic Acid

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Urogenital

Solution, sterile, for irrigation

0.25%*

0.25% Acetic Acid Irrigation

Adverse Reactions

Stinging or burning may be noted occasionally; local irritation has occurred very rarely.

Acetic Acid Dosage and Administration

Carefully remove all cerumen and debris to allow Acetic Acid Otic Solution to contact infected surfaces directly. To promote continuous contact, insert a wick of cotton saturated with the solution into the ear canal; the wick may also be saturated after insertion. Instruct the patient to keep the wick in for at least 24 hours and to keep it moist by adding 3 to 5 drops of the solution every 4 to 6 hours. The wick may be removed after 24 hours but the patient should continue to instill 5 drops of Acetic Acid Otic Solution 3 or 4 times daily thereafter, for as long as indicated. In pediatric patients, 3 to 4 drops may be sufficient due to the smaller capacity of the ear canal.

Overdose

No information provided.

Clinical pharmacology

Acetic acid is antibacterial and antifungal; propylene glycol is hydrophilic and provides a low surface tension; benzethonium chloride is a surface active agent that promotes contact of the solution with tissues.

Side Effects of Acetic Acid

Common side effects include:

  • temporary burning or stinging of the ear canal

These are not all the possible side effects of acetic acid. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

What is the most important information i should know about acetic acid (acetasol)?

Use this medication as directed on the label, or as your doctor has prescribed. Do not use the medication in larger amounts or for longer than recommended.

If you miss a dose, use it as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects are more likely, and you may have none at all. You may feel a slight burning or stinging when you first apply acetic acid ear drops. Talk to your doctor about any unusual or bothersome side effects.

(web3)