Name: Adapalene Topical
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What Is Differin (Adapalene)?
Differin is the brand name of the topical drug adapalene, which is used to treat acne.
The medicine is also sometimes prescribed to treat keratosis pilaris (a condition characterized by rough patches and small bumps on the skin) and other skin problems.
Differin belongs to a class of drugs called retinoid-like compounds. It works by stopping acne from forming under the skin.
The U.S. Food and Drug Administration (FDA) approved Differin in 1996 as a prescription drug; in July 2016, the FDA approved Differin for nonprescription (over-the-counter or OTC) sales. It's manufactured by Galderma Laboratories.
Before using Differin, let your doctor know if you have, or have ever had:
- Eczema (a skin condition)
- Allergies to medications
Differin can make your skin more sensitive to sunlight. Avoid prolonged sun exposure and tanning booths while using this medicine. Wear sunscreen, sunglasses, and protective clothing when outdoors.
Medicines similar to Differin have caused tumors in lab animals that were given the drugs and exposed to real or artificial sunlight. It's not known whether these effects apply to humans. Talk to your doctor about this risk.
Don't use hot wax to remove unwanted hair on areas where you apply Differin.
Your skin may worsen during the first few weeks of treatment with Differin. It can take 8 to 12 weeks before you notice the full benefits of this medicine.
Continue to use Differin even if your skin condition worsens. Don't stop taking the drug without first talking to your doctor.
Don't apply this medicine to skin that's broken, sunburned, chapped, or covered by eczema lesions.
Differin shouldn't be used by children younger than 12.
Don't get Differin in your eyes, nose, or mouth. If you accidently get it in your eyes, wash the area thoroughly with water and call your doctor.
Pregnancy and Differin
Differin may harm an unborn baby. Tell your doctor if you're pregnant or might become pregnant while using this medicine.
It's not known whether Differin passes into breast milk or could hurt a breastfeeding baby. Don't use Differin while breastfeeding without first talking to your doctor.
How to use
Uses For adapalene
Adapalene is used to treat acne. It works partly by keeping skin pores clear.
Adapalene is available only with your doctor's prescription.
How should I use adapalene topical?
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger amounts or for longer than recommended. Using adapalene topical in larger amounts than recommended will not make it work faster, and may cause unpleasant side effects.
Do not take by mouth. Adapalene is for use only on the skin.
Adapalene topical is usually applied once daily in the evening.
Wash your hands before applying this medicine.
Clean your skin with a mild non-medicated skin cleanser before applying the medicine. Pat the skin dry with a clean towel.
Apply a thin layer to the entire face or other affected skin areas. Avoid applying the medicine to the creases of your nose, or on your lips.
Do not apply to open wounds or on sunburned, windburned, dry, chapped, or irritated skin. Do not apply any other skin products unless your doctor has told you to.
Avoid getting this medicine in your eyes, nose, or mouth.
You may use a skin moisturizer if your skin becomes dry while using adapalene. Avoid creams or lotions that contain alpha hydroxy or glycolic acids.
It may take several weeks before your acne improves, and it may get slightly worse for a short time when you first start using adapalene. Keep using the medication as directed, even if you think it is not working.
Call your doctor if skin symptoms do not begin to improve within 8 to 12 weeks of using this medicine.
Do not use adapalene topical to treat any condition that has not been checked by your doctor.
Store at room temperature away from moisture and heat. Do not freeze.
What other drugs will affect adapalene topical?
It is not likely that other drugs you take orally or inject will have an effect on topically applied adapalene. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.
This medication is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Adapalene belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.
How to use Adapalene Gel
If you are using the over-the-counter product to self-treat, read and follow all directions on the product package before using this medication. If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, use it as directed.
Wash your hands before applying this medication. Gently clean the affected skin with a mild or soapless cleanser and pat dry. Use your fingertips to apply a small amount of medication in a thin layer, usually once daily at bedtime, or as directed by your doctor.
Use this medication on the skin only. Do not apply to the inner lip area or inside the nose/mouth. Do not apply to cut, scraped, sunburned, or skin affected by eczema (a skin disease).
Avoid getting this medication in your eyes. If this medication gets into your eyes, flush with large amounts of water. Call your doctor if eye irritation develops. Wash your hands after using the medication to avoid accidentally getting it in your eyes.
During the first few weeks of using adapalene, your acne might appear worse because the medication is working on pimples forming inside the skin. It may take up to 8-12 weeks to notice results from this medication.
Use it regularly in order to get the most benefit from it. To help you remember, use it at the same time each day. Do not use a larger amount or use it more often than recommended. Your skin will not improve any faster, and it will increase the risk of developing redness, peeling and pain.
This medication is available in different strengths and forms (such as gel, cream, lotion). The best type of medication for you to use will depend on the condition of your skin and your response to therapy. Tell your doctor if your condition lasts or gets worse.
A brief sensation of warmth or stinging may occur right after applying the medication. Skin redness, dryness, itching, scaling, mild burning, or worsening of acne may occur during the first 2-4 weeks of using the medication. These effects usually decrease with continued use. If any of these effects lasts or gets worse, tell your doctor or pharmacist promptly. Your doctor may want you to decrease how often you use adapalene, change the strength, or have you stop using it.
If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if any of these unlikely but serious side effects occur: very red/irritated skin, an intense burning sensation, eye redness and watering (conjunctivitis), eyelid swelling, skin discoloration.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.List Adapalene Gel side effects by likelihood and severity.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. This medication may be harmful if swallowed.
Do not share this medication with others.
Cosmetics may be used, but clean skin thoroughly before applying the medication.
Some cosmetics and soaps may worsen your acne. Moisturizers may be safe to use. When buying cosmetics, moisturizers or other skin care products, check the label for "non-comedogenic" or "non-acnegenic." These products are unlikely to worsen your acne. Ask your doctor or pharmacist which products are safe to use. Remember, acne is not caused by dirt. Cleaning your skin too often or too vigorously can irritate your skin and worsen acne.
If you forget to use this medication, use it as soon as you remember if you remember the same day. If you don't remember until morning, wait until your next dose is scheduled.
Store at room temperature away from light and moisture. Avoid freezing. Different forms of this medication may have different storage requirements. Read the package labeling or ask your pharmacist for the storage requirements for the product you are using. Gel preparations are flammable. Do not expose to heat or fire sources. Do not smoke during use. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.Information last revised March 2017. Copyright(c) 2017 First Databank, Inc.