Aflibercept Injection

Name: Aflibercept Injection

What special precautions should I follow?

Before receiving aflibercept injection,

  • tell your doctor and pharmacist if you are allergic to aflibercept, any other medications, or any of the ingredients in aflibercept injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
  • tell your doctor if you have an infection or swelling in or around the eye. Your doctor will probably tell you that you should not receive aflibercept injection.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving aflibercept injection, call your doctor.
  • you should know that aflibercept injection may cause vision problems. Do not drive a car or operate machinery until you know how this medication affects you.

What other information should I know?

Keep all appointments with your doctor.

Ask your pharmacist any questions you have about aflibercept injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Before Using aflibercept

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For aflibercept, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to aflibercept or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of aflibercept injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aflibercept injection in the elderly.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of aflibercept. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood clots, history of or
  • Detached retina (eye disorder) or
  • Endophthalmitis (inflammation of the eye) or
  • Glaucoma (increased pressure in the eye)—Use with caution. May make these conditions worse.
  • Eye infection—Should not be used in patients with this condition.

Proper Use of aflibercept

An eye doctor will give you aflibercept as a shot into the eye.

Precautions While Using aflibercept

Your eye doctor will want to check your progress at regular visits, especially during the first few days after you receive aflibercept.

If you are a woman who can bear children, use an effective form of birth control to keep from getting pregnant during treatment and for 3 months after the last dose of aflibercept. If you think you have become pregnant while using the medicine, tell your doctor right away.

Serious eye problems may occur with aflibercept. Check with your eye doctor right away if your eye becomes red, sensitive to light, or painful, or if you see flashes or sparks of light, have a change in vision, or feel increased pressure in the eye several days after the injection.

aflibercept may increase your risk of blood clots. Check with your doctor right away if you have pain in your chest, groin, or legs, especially the calves, difficulty with breathing, a severe, sudden headache, slurred speech, a sudden loss of coordination, severe weakness or numbness in your arm or leg, or vision changes.

aflibercept may cause temporary blurred vision. Avoid driving, using machines, or doing anything else that could be dangerous if you are not able to see well.

aflibercept Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
  • Blindness
  • bloody eye
  • blurred vision
  • eye or eyelid redness
  • eye pain
  • seeing flashes, sparks of light, or a veil or curtain
  • seeing floating spots before the eyes
  • vision changes
Less common
  • Bleeding or pain at the injection site
  • swelling of the eyelid
Rare
  • Fast heartbeat
  • fever
  • headache
  • hives, itching, rash, or skin redness
  • hoarseness
  • joint pain, stiffness, or swelling
  • swelling of the face, lips, hands, or feet
  • troubled breathing or swallowing
Incidence not known
  • Pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Feeling like something is in the eye
  • watery eyes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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