Canadian Brand Name
- Atropine Eye Ointment
- Atropine Ointment
- Minims Phenylephrine Hydrochloride
Rebel Distributors Corp..
AK-Pentolate™ (Cyclopentolate Hydrochloride Ophthalmic Solution) is an anticholinergic prepared as a sterile, borate buffered solution for topical ocular use. It is supplied in two strengths.
2-(Dimethylamino)ethyl 1-hydroxy-α-phenylcyclopentaneacetate hydrochloride
MW=327.85 C17H25NO3 • HCl
The active ingredient is represented by the structural formula:
AK-Pentolate™ (Cyclopentolate Hydrochloride Ophthalmic Solution) USP, 1% & 2%
Each mL contains: Active: Cyclopentolate Hydrochloride 10 mg (1%) or 20 mg (2%).
Preservative: Benzalkonium Chloride 0.1 mg (0.01%).
Inactives: Boric Acid, Edetate Disodium, Potassium Chloride (except 2% strength), Sodium Carbonate and/or Hydrochloric Acid may be added to adjust pH (3.0 to 5.5) and Purified Water USP.
Indications and Usage for AK-Pentolate
Cyclopentolate hydrochloride ophthalmic solution is used to produce mydriasis and cycloplegia.
Excessive dosage may produce behavioral disturbances, tachycardia, hyperpyrexia, hypertension, elevated intraocular pressure, vasodilation, urinary retention, diminished gastrointestinal motility and decreased secretion in salivary and sweat glands, pharynx, bronchi and nasal passages. Patients exhibiting signs of overdosage should receive supportive care and monitoring.
Hypersensitivity, untreated narrow angle glaucoma or increased IOP; untreated anatomically narrow angles
Sulfite sensitivity and other hypersensitivities; children with previous systemic reaction to atropine
Wait 5 min between drops
Transient elevatin in intraocular pressure may occur
Use caution in patients with Down syndrome (predisposed to angle-closure glaucoma)
Remove contact lenses prior to administration and wait 15 min before reinserting
The eldrely may be predisposed to increased intraocular pressure
The 2% solution may result in psychotic reactions and behavioral disturbances in children 30-45 min following instillation
Minimize absorption by using 1 drop of solution per eye and applying presure over the nasolacrimal sac for 2-3 min
These medicines may be absorbed into the body. Atropine passes into the breast milk in very small amounts and may cause side effects, such as fast pulse, fever, or dry skin, in babies of nursing mothers using ophthalmic atropine. It is not known whether homatropine or scopolamine passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are using one of these medicines and who wish to breast-feed should discuss this with their doctor.
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Brain damage (in children) or
- Down's syndrome (mongolism) (in children and adults) or
- Glaucoma or
- Spastic paralysis (in children)—Cyclopentolate may make the condition worse