Name: Akineton

US Brand Name

  1. Akineton


Each AKINETON tablet for oral administration contains 2 mg biperiden hydrochloride. Other ingredients may include corn syrup, lactose, magnesium stearate, potato starch and talc. AKINETON (biperiden) is an anticholinergic agent. Biperiden is a5-Norbornen-2-yl-a-phenyl-1-piperidinepropanol. It is a white, crystalline, odorless powder, slightly soluble in water and alcohol. It is stable in air at normal temperatures. Biperiden may be represented by the following structural formula:


  • As an adjunct in the therapy of all forms of parkinsonism (idiopathic, postencephalitic, arteriosclerotic)
  • Control of extrapyramidal disorders secondary to neuroleptic drug therapy (e.g., phenothiazines)

Akineton Overview

Akineton is a brand name medication included in a group of medications called Tertiary amines. For more information about Akineton see its generic Biperiden

Akineton Drug Class

Akineton is part of the drug class:

  • Tertiary amines

Uses for Akineton

Parkinsonian Syndrome

Adjunctive treatment of all forms of parkinsonian syndrome;a b more efficacious in postencephalic and idiopathic cases than in arteriosclerotic types.b

Relieves muscle rigidity, reduces sweating and salivation, improves gait, and to a lesser extent, tremor.a b

Drug-Induced Extrapyramidal Reactions

Control of extrapyramidal reactions induced by neuroleptic agents (e.g., phenothiazines).a b

Cautions for Akineton


  • Narrow angle glaucoma.a b

  • Bowel obstruction or megacolon.a b

  • Known hypersensitivity to biperiden or any ingredient in the formulation.a b



CNS Effects

Large or toxic doses or usual doses in patients with excess susceptibility may produce marked CNS disturbances (e.g., mental confusion, euphoria, agitation, disturbed behavior).a

Use with caution in patients with epilepsy.a

Ophthalmic Effects

Increased ocular tension associated with antimuscarinic use; however, such effect not reported with biperiden.a c Use with caution in patients with glaucoma.a

Cardiovascular Effects

Possible tachycardia; use with caution in patients with cardiac arrhythmias.a c

GU Effects

Possible urinary retention; use with caution in patients with prostatic hypertrophy.a c

Specific Populations


Category C.a b


Not known whether biperiden is distributed into milk.a b Caution advised if biperiden is used.a b

Pediatric Use

Safety and efficacy not established.a

Common Adverse Effects

Dry mouth, blurred vision, drowsiness, dizziness, constipation, agitation, mental confusion.a b

Commonly used brand name(s)

In the U.S.

  • Akineton

Available Dosage Forms:

  • Tablet

Therapeutic Class: Antiparkinsonian

Pharmacologic Class: Anticholinergic

Uses For Akineton

Biperiden is used alone or together with other medicines (e.g., levodopa) to treat Parkinson's disease. By improving muscle control and reducing stiffness, this medicine allows more normal movements of the body as the disease symptoms are reduced.

Biperiden is also used to control severe muscle reactions and other side effects from certain medicines that are used to treat severe nausea or nervous, mental, or emotional conditions (e.g., chlorpromazine [Thorazine®], perphenazine [Trilafon®], prochlorperazine [Compazine®], promethazine [Phenergan®], thioridazine [Mellaril®]).

This medicine is available only with your doctor's prescription.


Drug Interactions

The central anticholinergic syndrome can occur when anticholinergic agents such as Akineton are administered concomitantly with drugs that have secondary anticholinergic actions, e.g., certain narcotic analgesics such as meperidine, the phenothiazines and other antipsychotics, tricyclic antidepressants, certain antiarrhythmics such as the quinidine salts, and antihistamines. See OVERDOSAGE section for signs and symptoms of the central anticholinergic syndrome, and for treatment.


Pregnancy Category C

Animal reproduction studies have not been conducted with Akineton. It is also not known whether Akineton can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Akineton should be given to a pregnant woman only if clearly needed.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Akineton is administered to a nursing woman.

Pediatric Use

Safety and effectiveness in children have not been established.