Biologic Drug

Name: Biologic Drug

What is a biologic drug (biologics)?

  • A biologic drug (biologics) is a product that is produced from living organisms or contain components of living organisms.
  • Biologic drugs include a wide variety of products derived from human, animal, or microorganisms by using biotechnology.
  • Types of biologic drugs include vaccines, blood, blood components, cells, allergens, genes, tissues, and recombinant proteins.
  • Biologic products may contain proteins that control the action of other proteins and cellular processes, genes that control production of vital proteins, modified human hormones, or cells that produce substances that suppress or activate components of the immune system.
  • Biologic drugs are sometimes referred to as biologic response modifiers because they change the manner of operation of natural biologic intracellular and cellular actions.

What preparations are available for biologics?

Biologic drugs are administered by injection or infusion because they are proteins that are quickly digested and inactivated if given by mouth. Therefore, biologic drugs are supplied as powders for infusion or solutions for injection.

Which drugs or supplements interact with biologics?

  • Biologic drugs, for example, adalimubab (Humira), that affect the immune system may interfere with the effectiveness of vaccines. Live vaccines, including attenuated vaccines, should not be used while patients are being treated with biologics that affect the immune system. Patients should complete all recommended immunizations prior to receiving these types of biologic drygs. Prescreening for dormant tuberculosis (TB) generally is recommended.
  • Serious infections are more likely to occur when biologic drugs that suppress the immune system are combined with other drugs that also suppress the immune system.

What brand and generic names are available for biologics?

List of examples of brand and generic biologic drugs available in the US

  • abatacept (Orencia)
  • abciximab (ReoPro)
  • abobotulinumtoxinA (Dysport)
  • adalimumab (Humira)
  • adalimumab-atto (Amjevita)
  • ado-trastuzumab emtansine (Kadcyla)
  • aflibercept (Eylea)
  • agalsidase beta (Fabrazyme)
  • albiglutide (Tanzeum)
  • aldesleukin (Proleukin)
  • alemtuzumab (Campath, Lemtrada)
  • alglucosidase alfa (Myozyme, Lumizyme)
  • alirocumab (Praluent)
  • alteplase, cathflo activase (Activase)
  • anakinra (Kineret)
  • asfotase alfa (Strensiq)
  • asparaginase (Elspar)
  • asparaginase erwinia chrysanthemi (Erwinaze)
  • atezolizumab (Tecentriq)
  • basiliximab (Simulect)
  • becaplermin (Regranex)
  • belatacept (Nulojix)
  • belimumab (Benlysta)
  • bevacizumab (Avastin)
  • bezlotoxumab (Zinplava)
  • blinatumomab (Blincyto)
  • brentuximab vedotin (Adcetris)
  • canakinumab (Ilaris)
  • capromab pendetide (ProstaScint)
  • certolizumab pegol (Cimzia)
  • cetuximab (Erbitux)
  • collagenase (Santyl)
  • collagenase clostridium histolyticum (Xiaflex)
  • daclizumab (Zenapax)
  • daclizumab (Zinbryta)
  • daratumumab (Darzalex)
  • darbepoetin alfa (Aranesp)
  • denileukin diftitox (Ontak)
  • denosumab (Prolia, Xgeva)
  • dinutuximab (Unituxin)
  • dornase alfa (Pulmozyme)
  • dulaglutide (Trulicity)
  • ecallantide (Kalbitor)
  • eculizumab (Soliris)
  • elosulfase alfa (Vimizim)
  • elotuzumab (Empliciti)
  • epoetin alfa (Epogen/Procrit)
  • etanercept (Enbrel)
  • etanercept-szzs (Erelzi)
  • evolocumab (Repatha)
  • filgrastim (Neupogen)
  • filgrastim-sndz (Zarxio)
  • follitropin alpha (Gonal f)
  • galsulfase (Naglazyme)
  • glucarpidase (Voraxaze)
  • golimumab (Simponi)
  • golimumab injection (Simponi Aria)
  • ibritumomab tiuxetan (Zevalin)
  • idarucizumab (Praxbind)
  • idursulfase (Elaprase)
  • incobotulinumtoxinA (Xeomin)
  • infliximab (Remicade)
  • infliximab-dyyb (Inflectra)
  • interferon alfa-2b (Intron A)
  • interferon alfa-n3 (Alferon N Injection)
  • interferon beta-1a (Avonex, Rebif)
  • interferon beta-1b (Betaseron, Extavia)
  • interferon gamma-1b (Actimmune)
  • ipilimumab (Yervoy)
  • ixekizumab (Taltz)
  • laronidase (Aldurazyme)
  • mepolizumab (Nucala)
  • methoxy polyethylene glycol-epoetin beta (Mircera)
  • metreleptin (Myalept)
  • natalizumab (Tysabri)
  • necitumumab (Portrazza)
  • nivolumab (Opdivo)
  • obiltoxaximab (Anthim)
  • obinutuzumab (Gazyva)
  • ocriplasmin (Jetrea)
  • ofatumumab (Arzerra)
  • olaratumab (Lartruvo)
  • omalizumab (Xolair)
  • onabotulinumtoxinA (Botox)
  • oprelvekin (Neumega)
  • palifermin (Kepivance)
  • palivizumab (Synagis)
  • panitumumab (Vectibix)
  • parathyroid hormone (Natpara)
  • pegaspargase (Oncaspar)
  • pegfilgrastim (Neulasta)
  • peginterferon alfa-2a (Pegasys)
  • peginterferon alfa-2b (PegIntron, Sylatron)
  • peginterferon beta-1a (Plegridy)
  • pegloticase (Krystexxa)
  • pembrolizumab (Keytruda)
  • pertuzumab (Perjeta)
  • ramucirumab (Cyramza)
  • ranibizumab (Lucentis)
  • rasburicase (Elitek)
  • raxibacumab
  • reslizumab (Cinqair)
  • reteplase (Retavase)
  • rilonacept (Arcalyst)
  • rimabotulinumtoxinB (Myobloc)
  • rituximab (Rituxan)
  • romiplostim (Nplate)
  • sargramostim (Leukine)
  • sebelipase alfa (Kanuma)
  • secukinumab (Cosentyx)
  • siltuximab (Sylvant)
  • tbo-filgrastim (Granix)
  • tenecteplase (TNKase)
  • tocilizumab (Actemra)
  • trastuzumab (Herceptin)
  • ustekinumab (Stelara)
  • vedolizumab (Entyvio)
  • ziv-aflibercept (Zaltrap)

From

Arthritis Resources
  • Tips to Pamper Your Joints
  • Do You Need Back Surgery?
  • How Well Are You Living With AS?
Featured Centers
  • 13 Best Quit-Smoking Tips Ever
  • What Stress Does to Your Mouth
  • Healthy Home: To Buy or Not to Buy Organic?
Health Solutions From Our Sponsors
  • Frequent Constipation?
  • Greater Food Accessibility
Reviewed on 1/3/2017 References REFERENCES:

FDA. "What is a biological product?" Updated: May 31, 2016.
<http://www.fda.gov/AboutFDA/Transparency/Basics/ucm194516.htm>

FDA. "Complete List of Licensed Products and Establishments." Updated: Oct 31, 2016.
<http://www.fda.gov/BiologicsBloodVaccines/ucm133672.htm>
(web3)