Clarinex-D

Name: Clarinex-D

Uses of Clarinex-D

Clarinex-D is a prescription medicine used to treat the symptoms of seasonal allergic rhinitis (sneezing, stuffy nose, runny nose and itching of the nose) in patients 12 years and older. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

 

Inform MD

Before you take Clarinex-D, tell your doctor if you:

  • have any of the conditions listed in the section "Drug Precautions".
  • diabetes
  • hyperthyroidism
  • have prostate problems
  • have liver or kidney problems
  • have any other medical conditions
  • are pregnant or plan to become pregnant. It is not known if Clarinex-D will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. Clarinex-D can pass into your breast milk. Talk to your doctor about the best way to feed your baby if you take desloratadine/pseudoephedrine.

Tell your doctor about all the medicines your take, including prescription and non-prescription medicines, vitamins and herbal supplements.

Clarinex-D and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed. Clarinex-D can pass into your breast milk. Talk to your doctor about the best way to feed your baby if you take Clarinex-D.

Precautions While Using Clarinex-D

Desloratadine may cause dryness of the mouth, nose, and throat. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

In Summary

More frequently reported side effects include: headache, insomnia, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to desloratadine / pseudoephedrine: oral tablet extended release 12 hr, oral tablet extended release 24 hr

Along with its needed effects, desloratadine / pseudoephedrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking desloratadine / pseudoephedrine:

Observed during clinical practice
  • Abdominal or stomach pain area
  • chills
  • clay-colored stools
  • cough
  • dark urine
  • difficult or labored breathing
  • difficulty swallowing
  • dizziness
  • elevated liver enzymes
  • fast heartbeat
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • general tiredness and weakness
  • headache
  • hives
  • irregular heartbeat
  • itching
  • light-colored stools
  • loss of appetite
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • rash
  • redness of skin
  • shortness of breath
  • skin rash
  • swelling
  • tightness in chest
  • unpleasant breath odor
  • unusual tiredness or weakness
  • upper right abdominal pain
  • vomiting of blood
  • vomiting
  • welts
  • wheezing
  • yellow eyes or skin
Symptoms of overdose

Get emergency help immediately if any of the following symptoms of overdose occur while taking desloratadine / pseudoephedrine:

  • Increased heart rate
  • sleepiness or unusual drowsiness

Some side effects of desloratadine / pseudoephedrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Dry mouth
  • sleeplessness
  • trouble sleeping
  • unable to sleep
Less common
  • Body aches or pain
  • congestion
  • dryness or soreness of throat
  • hoarseness
  • nervousness
  • restlessness
  • runny nose
  • sleepiness or unusual drowsiness
  • tender, swollen glands in neck
  • trouble sitting still
  • voice changes
  • weight loss

For Healthcare Professionals

Applies to desloratadine / pseudoephedrine: oral tablet extended release

Cardiovascular

Cardiovascular side effects have included tachycardia and palpitations.[Ref]

Hypersensitivity

Hypersensitivity side effects have included rash, pruritus, urticaria, edema, dyspnea, and anaphylaxis.[Ref]

Nervous system

Nervous system side effects have included headache, insomnia, somnolence, dizziness, and hyperactivity.[Ref]

Hepatic

Hepatic side effects have included elevated liver enzymes including bilirubin and very rarely hepatitis.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea and anorexia.[Ref]

General

General side effects have included dry mouth, fatigue and pharyngitis.[Ref]

Some side effects of desloratadine / pseudoephedrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Desloratadine / pseudoephedrine Breastfeeding Warnings

Three mothers given pseudoephedrine demonstrated milk concentrations consistently higher than plasma concentrations. Maximum milk concentrations were reached at 1 to 1.5 hours after dosing. In one woman, the milk:plasma concentration ratio at 1, 3, and 12 hours was 3.3, 3.9, and 2.6. The authors calculated that 1000 mL of breast milk consumed over 24 hours would provide an infant with 0.25 to 0.33 mg of pseudoephedrine or 0.5% to 0.7% of the dose ingested by the mother.

Desloratadine and pseudoephedrine are excreted into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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