Colchicinum 4X Transdermal Gel

Name: Colchicinum 4X Transdermal Gel

Description

No information provided.

Indications

Gout Flares

ColciGel® transdermal gel is indicated for prophylaxis and the treatment of acute gout flares.

Treatment Of Gout Flares

ColciGel® gel is indicated for treatment of acute gout flares when used at the first sign of a flare.

Prophylaxis Of Gout Flares

ColciGel® is indicated for prophylaxis of gout flares.

Warnings

For External Use Only

  • Avoid Contact With Eyes and Mouth
  • Keep Out of Reach of Children Store at 25° C (77° F); exclusions permitted to 15° to 30°C (59° to 86° F). See USP Controlled Room Temperature

Clinical pharmacology

The mechanism by which colchicinum exerts its beneficial effect in patients has not been fully elucidated; however, evidence suggests that colchicinum may interfere with the intracellular assembly of the inflammasome complex present in neutrophils and monocytes that mediates activation of interleukin-1alpha. Additionally, colchicine disrupts cytoskeletal functions through inhibition of alphatubulin polymerization into microtubules and consequently prevents the activation, degranulation, and migration of neutrophils thought to mediate some gout symptoms.

Q

Side effects

Prophylaxis And Treatment Of Gout Flares

The most commonly reported adverse reaction in clinical trials for the prophylaxis and treatment of gout was mild skin irritation at the site of application.

Read the entire FDA prescribing information for ColciGel (Colchicinum 4X Transdermal Gel)

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