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What special precautions should I follow?
Before taking demeclocycline,
- tell your doctor and pharmacist if you are allergic to demeclocycline, tetracycline, minocycline, doxycycline, any other medications, or any of the ingredients in demeclocycline tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take, especially anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven), and penicillin. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- be aware that antacids containing magnesium, aluminum, or calcium, calcium supplements, iron products, and laxatives containing magnesium interfere with demeclocycline, making it less effective. Take demeclocycline 2 hours before or6 hours after antacids, calcium supplements, and laxatives containing magnesium. Take demeclocycline 2 hours before or4 hours after iron preparations and vitamin products that contain iron.
- tell your doctor if you have or have ever had lupus (condition in which the immune system attacks many tissues and organs including the skin, joints, blood, and kidneys), or kidney or liver disease.
- you should know that demeclocycline may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or injections). Talk to your doctor about using another form of birth control.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking demeclocycline, call your doctor immediately. Demeclocycline can harm the fetus.
- plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Demeclocycline may make your skin sensitive to sunlight. Tell your doctor right away if you get a sunburn.
- you should know that when demeclocycline is used during pregnancy or in babies or children up to age 8, it can cause the teeth to become permanently stained. Demeclocycline should not be used in children under age 8 unless your doctor decides it is needed.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
Demeclocycline Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using demeclocycline and call your doctor at once if you have a serious side effect such as:
- fever, chills, body aches, flu symptoms;
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
- pale skin, dark colored urine, jaundice (yellowing of the skin or eyes);
- confusion, mood changes, weakness, increased thirst or urination;
- swelling, weight gain, urinating less than usual or not at all;
- chest pain, wheezing, dry cough, rapid breathing, feeling short of breath;
- severe tingling, numbness, pain, muscle weakness;
- headache, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;
- sore throat and headache with a severe blistering, peeling, and red skin rash; or
- severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate.
Less serious side effects may include:
- sores or swelling in your rectal or genital area;
- mild nausea, vomiting, diarrhea, loss of appetite;
- white patches or sores inside your mouth or on your lips;
- swollen tongue, trouble swallowing; or
- vaginal itching or discharge.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
The following reactions have been reported in patients receiving tetracyclines:
Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, pancreatitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, increases in liver enzymes, and hepatic toxicity has been reported rarely.
Rarely, hepatitis and liver failure have been reported. These reactions have been caused by both the oral and parenteral administration of tetracyclines.
Instances of esophageal ulcerations have been reported in patients receiving oral tetracyclines. Most of the patients were reported to have taken the medication immediately before lying down. (See DOSAGE AND ADMINISTRATION.)
Skin: Maculopapular and erythematous rashes, erythema multiforme. Exfoliative dermatitis has been reported but is uncommon. Fixed drug eruptions and Stevens-Johnson syndrome have been reported rarely. Lesions occurring on the glans penis have caused balanitis. Pigmentation of the skin and mucous membranes has also been reported. Photosensitivity is discussed above. (See WARNINGS.)
Renal toxicity: Acute renal failure. Rise in BUN has been reported and is apparently dose related. Nephrogenic diabetes insipidus. (See WARNINGS.)
Hypersensitivity reactions: Urticaria, angioneurotic edema, polyarthralgia, anaphylaxis, anaphylactoid purpura, pericarditis exacerbation of systemic lupus erythematosus, lupus-like syndrome, pulmonary infiltrates with eosinophilia.
Hematologic: Hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia have been reported.
CNS: Pseudotumor cerebri (benign intracranial hypertension) in adults and bulging fontanels in infants (see PRECAUTIONS – General). Dizziness, headache, tinnitus, and visual disturbances have been reported. Myasthenic syndrome has been reported rarely.
Other: When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of thyroid glands. No abnormalities of thyroid function studies are known to occur. Very rare cases of abnormal thyroid function have been reported.
Tooth discoloration has occurred in pediatric patients less than 8 years of age (see WARNINGS), and has been reported rarely in adults.
Side Effects of Declomycin
Serious side effects have been reported with Declomycin. See the "Declomycin Precautions" section.
Common side effects of Declomycin include the following:
This is not a complete list of Declomycin side effects. Ask your doctor or pharmacist for more information.
Tell your doctor if you have any side effect that bothers you or that does not go away.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
What should i avoid while taking demeclocycline (declomycin)?
Do not take demeclocycline with milk or other dairy products, unless your doctor has told you to. Dairy products can make it harder for your body to absorb the medicine.
Demeclocycline may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid exposure to sunlight or tanning beds. Demeclocycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking demeclocycline. Also avoid a product that contains bismuth subsalicylate (such as Pepto-Bismol) within 2 hours before or after taking demeclocycline. These medications can make it harder for your body to absorb demeclocycline.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Actions and Spectrum
Usually bacteriostatic,100 a but may be bactericidal in high concentrations or against highly susceptible organisms.a
Inhibits protein synthesis100 in susceptible organisms by reversibly binding to 30S and 50S ribosomal subunits.a
The complete mechanisms by which tetracyclines reduce acne lesions have not been fully elucidated.a The effects appear to result in part from the antibacterial activity of the drugs, but other mechanisms also are involved.a
Spectrum of activity includes many gram-positive and -negative bacteria and various other organisms (e.g., Rickettsia, Chlamydia, Mycoplasma, spirochetes).a c Inactive against fungi and viruses.a
Gram-positive aerobes and anaerobes: active against Actinomyces israelii, Bacillus anthracis, Clostridium, Propionibacterium acnes, and some staphylococci and streptococci.a c Many strains of S. pyogenes and Enterococci are resistant.a
Gram-negative aerobes and anaerobes: active against Bartonella bacilliformis, Brucella, Calymmatobacterium granulomatis, Francisella tularensis, Haemophilus ducreyi, H. influenzae, Neisseria gonorrhoeae, Vibrio cholerae, and Y. pestis.100 Many strains of Acinetobacter, E. aerogenes, E. coli, Klebsiella, and Shigella and nearly all strains of Proteus and Pseudomonas are resistant.a c
Other organisms: active against Rickettsia, Coxiella burnetii, Chlamydia psittaci, C. trachomatis, Mycoplasma hominis, M. pneumoniae, Ureoplasma urealyticum, B. recurrentis, Leptospira, Treponema pallidum, and T. pertenue.a c
Complete cross-resistance usually occurs between demeclocycline and other tetracyclines (doxycycline, minocycline, oxytetracycline, tetracycline).a c
Usual Adult Dose for Bacterial Infection
150 mg orally 4 times a day or 300 mg orally twice a day