Depo-Provera (Medroxyprogesterone Injection (400 mg / mL))

Name: Depo-Provera (Medroxyprogesterone Injection (400 mg / mL))

What do I need to tell my doctor BEFORE I take Depo-Provera?

For all patients taking Depo-Provera:

  • If you have an allergy to medroxyprogesterone or any other part of this medicine.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have had any of these health problems: Bleeding disorder; blood clots or risk of having a blood clot; breast cancer; liver disease; heart attack; stroke; or tumor where estrogen or progesterone make it grow.
  • If you have had any of these health problems: Cancer of the uterus, ovary, cervix, or vagina; or vaginal bleeding where the cause is not known.

For all reasons other than cancer treatment:

  • If you are pregnant or may be pregnant. Do not take Depo-Provera if you are pregnant.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Depo-Provera with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Depo-Provera?

All products:

  • Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
  • Blood clots have happened with Depo-Provera. Tell your doctor if you have ever had a blood clot. Talk with your doctor.
  • Liver problems have happened. Call your doctor right away if you get signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • Have a bone density test as you have been told by your doctor. Talk with your doctor.
  • Take calcium and vitamin D as you were told by your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Be sure to have regular breast exams and gynecology check-ups. Your doctor will tell you how often to have these. You will also need to do breast self-exams as your doctor has told you. Talk with your doctor.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine.
  • This medicine may cause dark patches of skin on your face. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
  • If you are 65 or older, use Depo-Provera with care. You could have more side effects.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
  • If you will be trying to get pregnant, it may take some time after your last dose of this medicine to get pregnant. Talk with your doctor.

Cancer treatment:

  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Depo-Provera while you are pregnant.

What are some other side effects of Depo-Provera?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Weight gain.
  • Headache.
  • Dizziness.
  • Feeling sleepy.
  • Feeling nervous and excitable.
  • Upset stomach or throwing up.
  • Cramps.
  • Bloating.
  • Lowered interest in sex.
  • Pimples (acne).
  • Feeling tired or weak.
  • Enlarged breasts.
  • Vaginal bleeding or spotting.
  • Belly pain.
  • Leg cramps.
  • Swelling.
  • Not able to sleep.
  • Period (menstrual) changes. Periods become less often or stop.
  • Irritation where the shot is given.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take Depo-Provera or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Depo-Provera. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Review Date: October 4, 2017

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