Dolutegravir And Lamivudine (Oral Route)

Name: Dolutegravir And Lamivudine (Oral Route)

US Brand Name

  1. Dovato

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of dolutegravir and lamivudine combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dolutegravir and lamivudine combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution for patients receiving this medicine.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Dofetilide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aluminum
  • Amprenavir
  • Calcium
  • Carbamazepine
  • Dabrafenib
  • Dasabuvir
  • Efavirenz
  • Enzalutamide
  • Eslicarbazepine Acetate
  • Etravirine
  • Fosamprenavir
  • Fosphenytoin
  • Horsetail
  • Iron
  • Magaldrate
  • Magnesium
  • Metformin
  • Nevirapine
  • Orlistat
  • Oxcarbazepine
  • Phenytoin
  • Primidone
  • Rifampin
  • Rifapentine
  • Sorbitol
  • St John's Wort
  • Sucralfate
  • Tipranavir
  • Zinc

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For HIV infection:
      • Adults—One tablet once a day. Each tablet contains 50 milligrams (mg) dolutegravir and 300 mg lamivudine.
      • Children—Use and dose must be determined by your doctor.
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