Emapalumab-lzsg Injection

Name: Emapalumab-lzsg Injection

How should this medicine be used?

Emapalumab-lzsg comes as a liquid to be injected into a vein over 1 hour by a doctor or nurse in a hospital or medical facility. It is usually given 2 times per week, every 3 or 4 days, for as long as your doctor recommends that you receive treatment.

Your doctor may start you on a low dose of emapalumab-lzsg injection and gradually increase your dose, not more than once every 3 days.

Emapalumab-lzsg injection may cause a severe reaction during or shortly after the infusion of the medication. A doctor or nurse will monitor you carefully while you are receiving the medication. If you experience any of the following symptoms, tell your doctor immediately: skin redness, itching, fever, rash, excessive sweating, chills, nausea, vomiting, lightheadedness, dizziness, chest pain, or shortness of breath.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with emapalumab-lzsg injection and each time you receive the medication. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What side effects can this medication cause?

Emapalumab-lzsg injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • constipation
  • nose bleeds

Some side effects can be serious. If you experience any of these symptoms or those listed in the HOW section and SPECIAL PRECAUTIONS section, stop taking emapalumab-lzsg injection and call your doctor immediately or get emergency medical treatment:

  • fast, slow, or irregular heartbeat
  • fast breathing
  • muscle cramps
  • numbness and tingling
  • bloody or black, tarry stools
  • vomiting blood or brown material that resembles coffee grounds
  • decreased urination
  • swelling in the hands, feet, ankles, or lower legs

Emapalumab-lzsg injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will check your blood pressure regularly and will order certain lab tests before and during your treatment with emapalumab-lzsg injection to check your body's response to the medication.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

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