Inova 4 / 1 topical

Name: Inova 4 / 1 topical

What is Inova 4/1 (benzoyl peroxide and salicylic acid topical) (topical)?

Benzoyl peroxide has an antibacterial effect. It also has a mild drying effect that allows excess oil and dirt to be washed away.

Salicylic acid is a peeling agent that causes shedding of the outer layer of skin.

Benzoyl peroxide and salicylic acid topical (for the skin) is a combination medicine used to treat severe acne.

This medication is not for use in treating mild forms of acne. The strength of benzoyl peroxide contained in this medication is higher than that used in many over-the-counter acne products. Severe skin irritation can result from improper use of this product.

Benzoyl peroxide and salicylic acid topical may also be used for purposes not listed in this medication guide.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

This medicine side effects

Benzoyl peroxide and salicylic acid topical can cause a rare but serious allergic reaction or severe skin irritation. These reactions may occur just a few minutes after you apply the medicine, or within a day or longer afterward.

Stop using this medicine and get emergency medical help if you have any of these signs of an allergic reaction: hives, itching; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat.

Stop using benzoyl peroxide and salicylic acid topical and call your doctor at once if you have:

  • severe skin irritation after using the medicine;

  • scaly or peeling skin;

  • redness or swelling of treated skin; or

  • nausea, vomiting, diarrhea.

Common side effects may include:

  • dry skin or mild irritation;

  • dizziness; or

  • ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Consult your pharmacist.

How to use Inova 4-1 Combination Package

Consult your pharmacist.

For Healthcare Professionals

Applies to benzoyl peroxide / salicylic acid topical: topical pad


Excessive drying has been associated with skin peeling, irritation, erythema, and possible edema.[Ref]

Dermatologic side effects have included allergic contact dermatitis and excessive drying (4%).[Ref]


Gastrointestinal side effects including nausea, vomiting, and diarrhea have been reported.[Ref]

Nervous system

Nervous system side effects including dizziness, loss of hearing, tinnitus, and lethargy have been reported.[Ref]


Respiratory side effects including hyperpnea have been reported.[Ref]

Some side effects of Inova 4 / 1 may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.