Name: Kefzol

Why is this medication prescribed?

Cefazolin injection is used to treat certain infections caused by bacteria including skin, bone, joint, genital, blood, heart valve, respiratory tract (including pneumonia), biliary tract, and urinary tract infections. Cefazolin injection also may be used before, during, and sometimes for a brief period after surgery in order to prevent the patient from getting an infection. Cefazolin injection is in a class of medications called cephalosporin antibiotics. It works by killing bacteria.

Antibiotics such as cefazolin injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

How should this medicine be used?

Cefazolin injection comes as a powder to be mixed with liquid, or as a premixed product, to be injected intravenously (into a vein) over a period of 30 minutes. Cefazolin injection can also be given intramuscularly (into a muscle). It is usually given every 6, 8, or 12 hours. The length of your treatment depends on the type of infection you have and how your body responds to the medication.

You may receive cefazolin injection in a hospital or you may administer the medication at home. If you will be receiving cefazolin injection at home, your healthcare provider will show you how to use the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions.

You should begin to feel better during the first few days of treatment with cefazolin injection. If your symptoms do not improve or get worse, call your doctor.

Use cefazolin injection until you finish the prescription, even if you feel better. If you stop using cefazolin injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

What should I do if I forget a dose?

Use the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for a missed one.

Kefzol Drug Class

Kefzol is part of the drug class:

  • First generation cephalosporins

Kefzol Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • probenecid (Probalan, Benemid)
  • methotrexate (Rheumatrex, Trexall)
  • birth control pills

This is not a complete list of Kefzol drug interactions. Ask your doctor or pharmacist for more information.

Kefzol Precautions

Serious side effects have been reported with Kefzol including:

  • hypersensitivity (severe allergic reaction). This type of reaction may be serious and possibly fatal. These reactions are more likely to occur in those with a history of penicillin hypersensitivity and/or a history of sensitivity to multiple allergens. Tell your healthcare provider right away if you start to develop signs or symptoms of a hypersensitivity reaction, which include the following:
    • chest pain
    • swelling of the face, eyes, lips, tongue, arms, or legs
    • difficulty breathing or swallowing
    • fainting
    • rash
  • diarrhea. Diarrhea is a common problem caused by antibiotics, and it usually ends when the antibacterial is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as 2 or more months after having taken their last dose of the antibacterial. If diarrhea is severe or lasts more than 2 or 3 days, contact your doctor, as this may be a sign of an infection of the bowels.
  • superinfection: Kefzol should not be used for extended periods. Prolonged use can lead to the growth of dangerous organisms that are resistant to Kefzol. Take this medication for the duration prescribed by your doctor.
  • bleeding abnormalities. Your health care provider may want to monitor lab tests that show how well your blood is able to clot or that measure your tendency to bleed. Any abnormalities or irregularities that may occur may be more common in those with kidney dysfunction.
  • seizures. Some may experience a seizure when the dose of Kefzol exceeds the recommended dose, especially in the presence of kidney dysfunction.

Do not take Kefzol if you are allergic to any of its ingredients.

Kefzol Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Kefzol, there are no specific foods that you must exclude from your diet when receiving this medication.

Kefzol and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Kefzol has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from Kefzol, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.