Larotrectinib (Oral Route)

Name: Larotrectinib (Oral Route)

US Brand Name

  1. Vitrakvi

Descriptions

Larotrectinib is used to treat solid tumors (cancer) that are caused by certain abnormal NTRK genes and have spread or if surgery to remove the cancer is likely to cause severe complications, and there is no acceptable treatment option or the cancer grew or spread on other treatments.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Capsule
  • Solution

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acalabrutinib
  • Alfentanil
  • Apalutamide
  • Aprepitant
  • Avanafil
  • Boceprevir
  • Bosutinib
  • Budesonide
  • Buspirone
  • Carbamazepine
  • Clarithromycin
  • Cobicistat
  • Cobimetinib
  • Conivaptan
  • Darifenacin
  • Darunavir
  • Dasatinib
  • Dronedarone
  • Eletriptan
  • Enzalutamide
  • Eplerenone
  • Everolimus
  • Felodipine
  • Fluticasone
  • Fosaprepitant
  • Fosphenytoin
  • Ibrutinib
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ivabradine
  • Ivacaftor
  • Ketoconazole
  • Lopinavir
  • Lovastatin
  • Lumacaftor
  • Lurasidone
  • Maraviroc
  • Midazolam
  • Mitotane
  • Naloxegol
  • Nefazodone
  • Nelfinavir
  • Phenytoin
  • Posaconazole
  • Quetiapine
  • Rifampin
  • Ritonavir
  • Saquinavir
  • Sildenafil
  • Simvastatin
  • Sirolimus
  • St John's Wort
  • Telaprevir
  • Telithromycin
  • Temsirolimus
  • Ticagrelor
  • Tipranavir
  • Tolvaptan
  • Triazolam
  • Vardenafil
  • Venetoclax
  • Voriconazole

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the oral liquid in the refrigerator. Do not freeze. Throw away any unused oral liquid after 90 days of first opening the bottle.

(web3)