Leurocristine Sulfate

Name: Leurocristine Sulfate

Why is this medication prescribed?

Vincristine lipid complex is used to treat a certain type of acute lymphoblastic leukemia (ALL; a type of cancer of the white blood cells) that has not improved or that has worsened after at least two different treatments with other medications. Vincristine lipid complex is in a class of medications called vinca alkaloids. It works by slowing or stopping the growth of cancer cells in your body.

What special precautions should I follow?

Before receiving vincristine lipid complex,

  • tell your doctor and pharmacist if you are allergic to vincristine, any other medications, or any of the ingredients in vincristine lipid complex injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: aprepitant (Emend); carbamazepine (Tegretol); certain antifungals such as itraconazole (Sporanox), ketoconazole (Nizoral), voriconazole (Vfend), and posaconazole (Noxafil); clarithromycin (Biaxin, in Prevpac); dexamethasone (Decadron); HIV protease inhibitors including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); nefazodone; phenobarbital; phenytoin (Dilantin); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); rifapentine (Priftin);or telithromycin (Ketek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor what herbal products you are taking, especially St. John's wort.
  • tell your doctor if you have or have ever had a disorder that affects your nerves. Your doctor may not want you to receive vincristine lipid complex or may need to change your dose of vincristine lipid complex injection.
  • you should know that vincristine may interfere with the normal menstrual cycle (period) in women and may temporarily or permanently stop sperm production in men. Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should not become pregnant or breastfeed while you are receiving vincristine lipid complex. If you become pregnant while receiving vincristine lipid complex, call your doctor. Vincristine may harm the fetus.

What side effects can this medication cause?

Vincristine lipid complex may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • loss of appetite
  • stomach pain
  • diarrhea
  • trouble falling asleep or staying asleep

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected
  • constipation
  • fever, sore throat, ongoing cough and congestion, or other signs of infection
  • unusual bleeding or bruising
  • bloody or black, tarry stools
  • unusual tiredness or weakness
  • dizziness
  • pale skin
  • fast heartbeat
  • pain, burning, tingling, weakness in the hands or feet
  • difficulty walking
  • increased or decreased feeling or sensitivity to touch
  • decreased or absent reflexes
  • muscle or joint pain
  • jaw pain
  • sudden changes in vision
  • sudden decrease or loss of hearing
  • confusion or memory loss
  • sudden weakness on one side of the face

Vincristine may increase the risk that you will develop other cancers. Talk to your doctor about the risks of receiving vincristine lipid complex.

Vincristine lipid injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to vincristine lipid complex.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Marqibo® Kit

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

  • seizures
  • severe constipation
  • stomach pain
  • unusual bleeding or bruising
(web3)