Lomanate (as a combination product containing Atropine, Diphenoxylate)

Name: Lomanate (as a combination product containing Atropine, Diphenoxylate)

How should this medicine be used?

Diphenoxylate comes as a tablet and solution (liquid) to take by mouth. It is usually taken as needed up to 4 times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take diphenoxylate exactly as directed. Do not take more of it or take it more often than prescribed by your doctor.

The solution comes in a container with a special dropper for measuring the dose. Ask your pharmacist if you have questions about how to measure a dose.

Your diarrhea symptoms should improve within 48 hours of treatment with diphenoxylate. Your doctor may tell you to decrease your dose as your symptoms improve. If your symptoms do not improve or if they get worse within 10 days of treatment, call your doctor.

Diphenoxylate can be habit-forming. Do not take a larger dose, take it more often, or for a longer period of time than your doctor tells you to. Atropine has been added to diphenoxylate tablets to cause unpleasant effects if this medication is taken in higher doses than recommended.

Other uses for this medicine

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special dietary instructions should I follow?

Be sure to follow all dietary recommendations made by your doctor. Drink plenty of clear liquids to replace fluids lost while having diarrhea.

What side effects can this medication cause?

Diphenoxylate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • loss of appetite
  • headache
  • restlessness
  • tiredness
  • confusion
  • changes in mood
  • dryness of the skin, nose, or mouth

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • numbness in arms and legs
  • decreased urination
  • ongoing pain that begins in the stomach area, but may spread to the back
  • abdominal bloating
  • fast heart beat
  • shortness of breath
  • hives
  • rash
  • itching
  • swelling of the eyes, face, tongue, lips, gums, mouth, hands, feet, ankles, or lower legs
  • difficulty swallowing or breathing
  • hoarseness

Diphenoxylate may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else take your medication. Diphenoxylate is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names of combination products

  • Colonaid® (containing Atropine, Diphenoxylate)
  • Di-Atro® (containing Atropine, Diphenoxylate)
  • Lo-Trol® (containing Atropine, Diphenoxylate)
  • Logen® (containing Atropine, Diphenoxylate)
  • Lomanate® (containing Atropine, Diphenoxylate)
  • Lomotil® (containing Atropine, Diphenoxylate)
  • Lonox® (containing Atropine, Diphenoxylate)
  • Low-Quel® (containing Atropine, Diphenoxylate)
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