Nusinersen injection

Name: Nusinersen injection

What side effects can this medication cause?

Nusinersen injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • fever, sore throat, or other signs of infection
  • constipation
  • rash

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • headache, which may occur along with lower back pain, nausea, vomiting, dizziness, ringing in the ears, and changes in vision
  • unusual bleeding or bruising
  • decreased urination
  • pink or brown-colored urine

Nusinersen injection may slow an infant's growth. Your child's doctor will watch his or her growth carefully. Talk to your child's doctor if you have concerns about your child's growth while he or she is receiving this medication.

Nusinersen injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain labs before and during treatment to check your body's response to nusinersen injection.

Ask your pharmacist any questions you have about nusinersen injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

What should I discuss with my healthcare provider before receiving nusinersen?

You should not be treated with nusinersen if you are allergic to it.

To make sure nusinersen is safe for you, tell your doctor if you have:

  • kidney disease.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether nusinersen passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

What other drugs will affect nusinersen?

Other drugs may interact with nusinersen, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Usual Pediatric Dose for Spinal Muscular Atrophy

17 years and older: Use adult dosing

Renal Dose Adjustments

Data not available

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