Nusinersen Sodium

Name: Nusinersen Sodium

Introduction

Nusinersen sodium is a survival motor neuron-2 (SMN2)-directed antisense oligonucleotide.1

Nusinersen Sodium Dosage and Administration

General

Nusinersen sodium is available in the following dosage form(s) and strength(s):

Injection: 12 mg/5 mL (2.4 mg/mL) in a single-dose vial.1

Dosage

It is essential that the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:

Nusinersen sodium is administered intrathecally.1

    Dosing Information1
  • Available as nusinersen sodium; dosage expressed in terms of nusinersen.1

  • The recommended dosage is 12 mg (5 mL) per administration.1

  • Initiate nusinersen sodium treatment with 4 loading doses; the first three loading doses should be administered at 14-day intervals; the 4th loading dose should be administered 30 days after the 3rd dose; a maintenance dose should be administered once every 4 months thereafter.1

    Important Preparation and Administration Instructions1
  • Allow to warm to room temperature prior to administration. 1

  • Administer within 4 hours of removal from vial. 1

  • Prior to administration, remove 5 mL of cerebrospinal fluid. 1

  • Administer as intrathecal bolus injection over 1 to 3 minutes. 1

    Laboratory Testing and Monitoring to Assess Safety1
  • At baseline and prior to each dose, obtain a platelet count, coagulation laboratory testing, and quantitative spot urine protein testing.1

Drug Interactions

Specific Drugs

It is essential that the manufacturer's labeling be consulted for more detailed information on interactions with this drug, including possible dosage adjustments. Interaction highlights:

Please see product labeling for drug interaction information.

Actions

Specific Drugs

It is essential that the manufacturer's labeling be consulted for more detailed information on interactions with this drug, including possible dosage adjustments. Interaction highlights:

Please see product labeling for drug interaction information.

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Nusinersen Sodium

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Parenteral

Injection, Solution

2.4 mg /1 mL (of nusinersen)

Spinraza

Biogen

(web3)