Name: Ofloxacin (Systemic)
- Ofloxacin Systemic side effects
- Ofloxacin Systemic effects of
- Ofloxacin Systemic drug
- Ofloxacin Systemic 200 mg
What are some other side effects of Ofloxacin?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Upset stomach or throwing up.
- Not able to sleep.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
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Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Generic: 200 mg [DSC], 300 mg, 400 mg
Ofloxacin is a DNA gyrase inhibitor. DNA gyrase is an essential bacterial enzyme that maintains the superhelical structure of DNA. DNA gyrase is required for DNA replication and transcription, DNA repair, recombination, and transposition; bactericidal
Widely distributed into body tissues and fluids, including blister fluid, cervix, lung, ovary, prostatic tissue, skin, and sputum; Vd: 2.4 to 3.5 L/kg
Urine: 65% to 80% (as unchanged drug); feces: 4% to 8%; <10% is metabolized
Time to Peak
Serum: 1 to 2 hours
~9 hours (biphasic: 4 to 5 hours [6.4 to 7.4 hours in elderly patients] and 20 to 25 hours [accounts for <5%]); prolonged with renal impairment
20% to 32%
Monitor CBC, renal and hepatic function periodically if therapy is prolonged.