Pediazole (as a combination product containing Erythromycin, Sulfisoxazole)

Name: Pediazole (as a combination product containing Erythromycin, Sulfisoxazole)

What special dietary instructions should I follow?

Do not take this medication with, or just after, fruit juices, carbonated drinks, or tea. It can be taken with or between meals.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Erythromycin and sulfisoxazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • upset stomach
  • diarrhea
  • vomiting
  • stomach cramps
  • mild skin rash

If you experience any of the following symptoms, call your doctor immediately:

  • severe skin rash
  • itching
  • hives
  • difficulty breathing or swallowing
  • wheezing
  • stomach pain
  • yellowing of the skin or eyes
  • dark urine
  • pale stools
  • unusual tiredness
  • sore throat
  • fever
  • joint pain
  • blood in urine
  • unusual bleeding or bruising
  • dark, tarry stools

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Keep it in the refrigerator, and dispose of any unused medication after 14 days. Do not freeze.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Brand names of combination products

  • Eryzole® (containing Erythromycin, Sulfisoxazole)
  • Ilosone® (containing Erythromycin, Sulfisoxazole)
  • Pediazole® (containing Erythromycin, Sulfisoxazole)