Pimavanserin

Name: Pimavanserin

Uses of Pimavanserin

Pimavanserin is a prescription medication used to treat hallucinations and delusions associated with psychosis experienced by some people with Parkinson’s disease.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Pimavanserin Brand Names

Pimavanserin may be found in some form under the following brand names:

  • Nuplazid

Pimavanserin Drug Class

Pimavanserin is part of the drug class:

  • ANTIPSYCHOTICS

Pimavanserin and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if pimavanserin crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with the use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using pimavanserin.

Pimavanserin Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fast or pounding heartbeats;
  • headache with chest pain; or
  • severe dizziness.

Common side effects may include:

  • confusion; or
  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I take pimavanserin?

Pimavanserin is usually taken once daily. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

You may take pimavanserin with or without food.

Your pimavanserin dose may need to be adjusted up or down if you use certain other medications, especially an antibiotic or antifungal medicine, heart or blood pressure medicine, seizure medication, or drugs to treat HIV, hepatitis, or tuberculosis. It is very important to tell your doctor if you start or stop using any other medications.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Store at room temperature away from moisture and heat.

Pimavanserin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fast or pounding heartbeats;

  • headache with chest pain; or

  • severe dizziness.

Common side effects may include:

  • confusion; or

  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

pimavanserin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known
  • Chest pain or discomfort
  • fainting
  • irregular or slow heart rate
  • shortness of breath

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • confusion
  • nausea
  • rapid weight gain
  • unusual weight gain or loss
Less common
  • Change in walking and balance
  • clumsiness or unsteadiness
  • difficulty having a bowel movement (stool)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Uses of Pimavanserin

  • It is used to treat hallucinations (seeing or hearing things that are not there) and strange thoughts that happen with Parkinson's disease.

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Tablet, Oral:

Nuplazid: 17 mg [contains saccharin sodium]

Dosing Renal Impairment

Note: Renal function may be estimated using the Cockcroft-Gault formula for dosage adjustment purposes.

CrCL ≥30 mL/minute: No dosage adjustment necessary.

CrCL <30 mL/minute: Use is not recommended; has not been studied in patients with severe renal impairment.

For the Consumer

Applies to pimavanserin: oral tablet

Along with its needed effects, pimavanserin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pimavanserin:

Incidence not known
  • Chest pain or discomfort
  • fainting
  • irregular or slow heart rate
  • shortness of breath

Some side effects of pimavanserin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • confusion
  • nausea
  • rapid weight gain
  • unusual weight gain or loss
Less common
  • Change in walking and balance
  • clumsiness or unsteadiness
  • difficulty having a bowel movement (stool)

Usual Adult Dose for Psychosis

Recommended dose: 34 mg (as two 17 mg tablets) orally once a day

Comment:
-This drug does not require titration.

Use: Treatment of hallucinations and delusions associated with Parkinson's disease psychosis

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