Premarin I.V.

Name: Premarin I.V.

How should this medicine be used?

The estradiol cypionate and estradiol valerate forms of long acting estrogen injection come as a liquid to inject into a muscle. These medications are usually injected by a health care professional once every 3 to 4 weeks. When the estradiol valerate form of estrogen injection is used to treat the symptoms of prostate cancer, it is usually injected by a health care professional once every 1 to 2 weeks.

The conjugated estrogens form of estrogen injection comes as a powder to mix with sterile water and inject into a muscle or vein. It is usually injected by a health care professional as a single dose. A second dose may be injected 6 to 12 hours after the first dose if it is needed to control vaginal bleeding.

If you are using estrogen injection to treat hot flushes, your symptoms should improve within 1 to 5 days after you receive the injection. Tell your doctor if your symptoms do not improve during this time.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special dietary instructions should I follow?

Talk to your doctor about eating grapefruit and drinking grapefruit juice while using this medicine.

What should I do if I forget a dose?

If you miss an appointment to receive a dose of estrogen injection, call your doctor as soon as possible.

What side effects can this medication cause?

Estrogen injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • breast pain or tenderness
  • upset stomach
  • vomiting
  • weight gain or loss
  • dizziness
  • nervousness
  • depression
  • irritability
  • changes in sexual desire
  • hair loss
  • unwanted hair growth
  • spotty darkening of the skin on the face
  • difficulty wearing contact lenses
  • leg cramps
  • swelling, redness, burning, itching, or irritation of the vagina
  • vaginal discharge

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

  • bulging eyes
  • pain, swelling, or tenderness in the stomach
  • loss of appetite
  • weakness
  • yellowing of the skin or eyes
  • joint pain
  • movements that are difficult to control
  • rash or blisters
  • hives
  • itching
  • swelling of the eyes, face, tongue, throat, hands, arms, feet, ankles, or lower legs
  • hoarseness
  • difficulty breathing or swallowing

Estrogen may increase your risk of developing cancer of the ovaries or gallbladder disease that may need to be treated with surgery. Talk to your doctor about the risks of using estrogen injection.

Estrogen may cause growth to slow or stop early in children who receive large doses for a long time. Estrogen injection may also affect the timing and speed of sexual development in children.Your child's doctor will monitor him or her carefully during his or her treatment with estrogen. Talk to your child's doctor about the risks of giving this medication to your child.

Estrogen injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Your doctor will store the medication in his or her office.

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