Sanctura XR

Name: Sanctura XR

Inform MD

Before taking Sanctura XR, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Sanctura XR or to any of its ingredients
  • have any stomach or intestinal problems or problems with constipation
  • have trouble emptying your bladder or have a weak urine stream
  • have an eye problem called narrow-angle glaucoma
  • have kidney problems
  • have liver problems
  • are pregnant or plan to become pregnant. It is not known if Sanctura XR can harm your unborn baby. 
  • are breastfeeding or plan to breastfeed. It is not known if Sanctura XR passes into breast milk and if it can harm your baby. You should talk to your doctor about the best way to feed your baby if you are taking Sanctura XR.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Sanctura XR and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Sanctura XR crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Speak to your doctor about the best way to feed your baby if you are taking Sanctura XR.

Sanctura XR Usage

Take Sanctura XR exactly as prescribed.

Sanctura XR comes in capsule form.  

Take one Sanctura XR capsule daily in the morning with water.

Take Sanctura XR on an empty stomach or at least 1 hour before a meal.

Do not take alcohol within 2 hours of taking Sanctura XR.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Sanctura XR at the same time.

What should I discuss with my healthcare provider before taking Sanctura XR (trospium)?

You should not use trospium if you are allergic to it, or if you have:

  • untreated or uncontrolled narrow-angle glaucoma;

  • a blockage in your digestive system; or

  • if you are unable to urinate.

To make sure you can safely take trospium, tell your doctor if you have any of these other conditions:

  • glaucoma;

  • liver disease;

  • kidney disease;

  • a stomach or intestinal disorder such as ulcerative colitis;

  • a muscle disorder such as myasthenia gravis; or

  • an enlarged prostate.

FDA pregnancy category C. It is not known whether trospium will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether trospium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more likely to have side effects from this medicine.

How should I take Sanctura XR (trospium)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take trospium on an empty stomach, at least 1 hour before a meal. Extended-release trospium (Sanctura XR) should be taken once each morning, at least 1 hour before a meal.

Do not crush, chew, break, or open an extended-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

Store at room temperature away from moisture and heat.

What are some things I need to know or do while I take Sanctura XR?

  • Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how Sanctura XR affects you.
  • Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
  • Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
  • Do not drink alcohol within 2 hours of taking this medicine.
  • A very bad reaction called angioedema has happened with Sanctura XR. Sometimes, this may be life-threatening. Signs may include swelling of the hands, face, lips, eyes, tongue, or throat; trouble breathing; trouble swallowing; or unusual hoarseness. Talk with the doctor.
  • If you are 65 or older, use this medicine with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Sanctura XR while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

What are some other side effects of Sanctura XR?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Hard stools (constipation).
  • Dry mouth.
  • Headache.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

In Summary

Common side effects of Sanctura XR include: constipation and xerostomia. Other side effects include: xerophthalmia and dry nose. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to trospium: oral capsule extended release, oral tablet

Along with its needed effects, trospium (the active ingredient contained in Sanctura XR) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trospium:

More common
  • Bladder pain
  • bloody or cloudy urine
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult or burning urination
  • difficulty in passing urine (dribbling)
  • frequent urge to urinate
  • lower back or side pain
  • painful urination
Less common
  • Chills
  • cough
  • diarrhea
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
Incidence not known
  • Blistering, peeling, or loosening of the skin
  • changes in vision
  • clammy skin
  • confusion as to time, place, or person
  • dark-colored urine
  • difficulty with swallowing
  • dizziness
  • enlarged pupils
  • fainting
  • fast or slow heartbeat
  • hallucinations
  • hives
  • holding false beliefs that cannot be changed by fact
  • increased sensitivity of the eyes to light
  • increased sweating, possibly with fever or cold
  • itching
  • muscle cramps or spasms
  • muscle stiffness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seeing, hearing, or feeling things that are not there
  • severe chest pain
  • severe headache
  • shortness of breath
  • skin rash
  • sores, ulcers, or white spots in the mouth or on the lips
  • stiff or sore neck
  • tightness in the chest
  • unusual excitement, nervousness, or restlessness
  • wheezing

Some side effects of trospium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Back pain
  • blurred vision
  • difficulty having a bowel movement (stool)
  • dry mouth
  • dry skin
  • sleepiness or unusual drowsiness
Less common
  • Acid or sour stomach
  • belching
  • bloated or full feeling
  • dry eyes
  • excess air or gas in the stomach or intestines
  • heartburn
  • indigestion
  • passing gas
  • stomach discomfort, upset, or pain
  • stuffy nose
  • trouble with urinating
  • unable to have a bowel movement (stool)
  • upper stomach pain
Incidence not known
  • Burning feeling in the chest or stomach
  • change in taste
  • dry throat
  • indigestion
  • loss of taste
  • swelling of the abdomen or stomach area
  • tenderness in the stomach area

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