Silver Sulfadiazine

Name: Silver Sulfadiazine

Silver Sulfadiazine Interactions

This is not a complete list of Silver Sulfadiazinedrug interactions. Ask your doctor or pharmacist for more information.


Sulfonamide; synthetic anti-infective agent.a b c e g h i j l

Actions and Spectrum

  • Mechanism of action of silver sulfadiazine appears to differ from sulfadiazine and silver nitrate; acts on cell membrane and cell wall to produce bactericidal effects.a b c g

  • Wide spectrum of activity against most burn pathogens, including species of both gram-positive and gram-negative organisms, including most species of Klebsiella, Proteus, Pseudomonas, and Staphylococcus.a b c Also inhibits Escherichia coli, Corynebacterium diphtheriae, and species of Acinetobacter, Citrobacter, Enterobacter, Providencia, Serratia, and streptococci.a b c Also has some activity against Candida albicans, Herpesvirus hominis, and Clostridium perfringens.a b c

  • Resistance reported occasionally.c

Pharmacologic Category

  • Antibiotic, Topical


For topical use only; avoid contact with eyes. Apply with a sterile-gloved hand. Burned area should be covered with cream at all times; reapply to areas where cream has been removed by patient activity. Dressings may be used if necessary. Reapply immediately after hydrotherapy.

Test Interactions

Propylene glycol may affect the interpretation of laboratory tests.