Sodium 2-mercaptoethanesulfonate

Name: Sodium 2-mercaptoethanesulfonate

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Brand names

  • Mesnex®

Other names

  • Sodium 2-mercaptoethanesulfonate

Why is this medication prescribed?

Mesna is used to reduce the risk of hemorrhagic cystitis (a condition that causes inflammation of the bladder and can result in serious bleeding) in people who receive ifosfamide (a medication used for the treatment of cancer). Mesna is in a class of medications called cytoprotectants. It works by protecting against some of the harmful effects of certain chemotherapy medications.

How should this medicine be used?

Mesna comes as a solution (liquid) to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given at the same time as you receive your chemotherapy treatment and then 4 and 8 hours after your chemotherapy treatment.

Drink at least 1 quart (4 cups; about 1 liter) of fluid daily while you are receiving mesna injection.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

Mesna is also sometimes used to reduce the risk of hemorrhagic cystitis in people who receive the chemotherapy drug cyclophosphamide. Talk to your doctor about the risks of using this medication for your condition.

What special precautions should I follow?

Before receiving mesna injection,

  • tell your doctor and pharmacist if you are allergic to mesna, any other medications, or any of the ingredients in mesna injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
  • tell your doctor if you have or have ever had an autoimmune disorder (a condition that occurs when your immune system mistakenly attacks healthy body tissue) such as rheumatoid arthritis, systemic lupus erythematosus, or nephritis (a type of kidney problem).
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.
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