SSD Cream

Name: SSD Cream

Dosing & Uses

Dosage Forms & Strengths

cream

  • 1%

Burn Wound Infections (2°/3°)

1% cream: Apply qDay-q12hr to burn

Dosage Forms & Strengths

cream

  • 1%

Burn Wound Infections (2°/3°)

<2 months: Contraindicated

>2 months (1% cream): Apply qDay-q12hr to burn

Adverse Effects

Frequency Not Defined

Pain

Burning

Itching

Rash

Necrosis of the skin

Erythema multiforme

Transient skin discoloration

Hemolytic anemia (in patients with G6PD deficiency)

Agranulocytosis

Aplastic anemia

Thrombocytopenia

Leukopenia

Dermatologic and hypersensitivity reactions (eg, Stevens-Johnson syndrome, TEN)

Adverse GI effects

Hepatitis and hepatocellular necrosis

Adverse nervous system effects

Toxic nephrosis

Interstitial nephritis

Pharmacology

Mechanism of Action

Acts on cell membrane and cell wall

Absorption

Peak plasma time: 3-11 days

Elimination

Half-life: 10 hr

Excretion: Urine (50%)

What should I do if I forget a dose?

Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.

Warning


There is a potential cross-sensitivity between silver sulfadiazine and other sulfonamides.  If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction.  

Fungal proliferation in and below the eschar may occur.  However, the incidence of clinically reported fungal superinfection is low.

The use of Silver Sulfadiazine Cream in some cases of glucose-6-phosphate dehydrogenase-deficient individuals may be hazardous, as hemolysis may occur.

Precaution

If hepatic and renal functions become impaired and elimination of the drug decreases accumulation may occur and discontinuation of Silver Sulfadiazine Cream should be weighed against the therapeutic benefit being achieved.

In considering the use of topical proteolytic enzymes in conjunction with Silver Sulfadiazine Cream, the possibility should be noted that silver may inactivate such enzymes.

Laboratory Tests: In the treatment of burn wounds involving extensive areas of the body, the serum sulfa concentrations may approach adult therapeutic levels (8 to 12mg %).  Therefore, in these patients it would be advisable to monitor serum sulfa concentrations.  Renal function should be carefully monitored and the urine should be checked for sulfa crystals. 

Absorption of the propylene glycol vehicle has been reported to affect serum osmolality, which may affect the interpretation of laboratory tests.


Container Label for 25 g Tube


SSD™
NDC 43598-210-25
Dr. Reddy’s
25 Grams
1% Silver Sulfadiazine Cream 1%
FOR TOPICAL USE ONLY
NOT FOR OPHTHALMIC USE
Rx Only

Silver Sulfadiazine…10mg/g
in a hydrophilic base consisting of cetyl alcohol, isopropyl myristate, polyoxyl 40 stearate, propylene glycol, purified water, stearyl alcohol, sodium hydroxide, sorbitan monooleate, white petrolatum; with 0.3% methylparaben, as a preservative. See full prescribing information for dosage and administration.
Store at controlled room 15° - 30°C (59° - 86°F).
SSD is a trademark of Dr. Reddy’s Laboratories, Inc.
Manufactured by
Dr. Reddy's Laboratories Louisiana, LLC
Shreveport, LA 71106 USA

Container Label for 50 g Jar


SSD™
NDC 43598-210-55
Dr. Reddy’s
85 Grams
1% Silver Sulfadiazine Cream 1%
FOR TOPICAL USE ONLY
NOT FOR OPHTHALMIC USE
Rx Only

Silver Sulfadiazine…10mg/g
in a hydrophilic base consisting of cetyl alcohol, isopropyl myristate, polyoxyl 40 stearate, propylene glycol, purified water, stearyl alcohol, sodium hydroxide, sorbitan monooleate, white petrolatum; with 0.3% methylparaben, as a preservative. See full prescribing information for dosage and administration.
Store at controlled room 15° - 30°C (59° - 86°F).
SSD is a trademark of Dr. Reddy’s Laboratories, Inc.
Manufactured by
Dr. Reddy's Laboratories Louisiana LLC
Shreveport, LA 71106 USA

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