Symlin Pen

Name: Symlin Pen

How should this medicine be used?

Pramlintide comes as a solution (liquid) in a prefilled dosing pen to inject subcutaneously (just under the skin). It is usually injected several times a day, before each meal that includes at least 250 calories or 30 grams of carbohydrate. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use pramlintide exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Pramlintide controls diabetes but does not cure it. Continue to use pramlintide even if you feel well. Do not stop using pramlintide without talking to your doctor. If you do stop using pramlintide for any reason, do not start using it again without talking to your doctor.

Be sure you know what other supplies, such as needles, you will need to inject your medication. Ask your doctor or pharmacist what type of needles you will need to inject your medication. Carefully read and understand the manufacturer's instructions for injecting pramlintide using the pen. Also make sure you know how and when to set up a new pen. Ask your doctor or pharmacist to show you how to use the pen. Follow the directions carefully. Do not mix pramlintide with insulin.

Always look at your pramlintide pen solution before you inject it. It should be clear and colorless. Do not use pramlintide if it is colored, cloudy, thickened, contains solid particles, or if the expiration date on the package label has passed.

Never reuse needles and never share needles or pens. Always remove the needle right after you inject your dose. Dispose of needles in a puncture-resistant container. Ask your doctor or pharmacist how to dispose of the puncture resistant container.

You can inject pramlintide anywhere on your stomach or thigh. Do not inject pramlintide into your arm. Choose a different spot to inject pramlintide every day. Be sure that the spot you choose is more than 2 inches away from the spot where you will inject insulin.

You should inject pramlintide under the skin the same way that you inject insulin. Allow the pramlintide pen to warm to room temperature before you inject the medication. If you have questions about injecting pramlintide, ask your doctor or pharmacist.

What special precautions should I follow?

Before using pramlintide injection,

  • tell your doctor and pharmacist if you are allergic to pramlintide, any other medications, metacresol, or any other ingredients in the pramlintide pen. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: acarbose (Precose); antihistamines; atropine (Atropen, in Lomotil, others); certain antidepressants ('mood elevators') called tricyclic antidepressants; certain medications to treat asthma, diarrhea, lung disease, mental illness, motion sickness, overactive bladder, pain, Parkinson's disease, stomach or intestinal cramps, ulcers, and upset stomach; laxatives;miglitol (Glyset); and stool softeners. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • if you are taking oral contraceptives (birth control pills), pain medications, or antibiotics, take them at least 1 hour before or 2 hours after you use pramlintide.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using pramlintide, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are using pramlintide.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store unopened pramlintide pens in the refrigerator and protect from light; do not freeze the pens. Dispose of any pens that were frozen or exposed to heat. You may store opened pramlintide pens in the refrigerator or at room temperature, but you must use them within 30 days. Dispose of any opened pramlintide pens after 30 days.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

  • upset stomach
  • vomiting
  • diarrhea
  • dizziness
  • flushing

What other information should I know?

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Symlin Pen®