Tacrolimus Injectable Solution

Name: Tacrolimus Injectable Solution

Highlights for tacrolimus

TACROLIMUS (ta KROE li mus) is used to prevent organ rejection after a transplant.

This drug also comes in other forms, including Topical ointment, Oral capsule, Oral tablet

This drug can cause serious side effects. See which side effects you should report to your doctor right away.

Know how to use your medication, and learn what might happen if you miss a dose.

Talk to your healthcare provider if you have any of these conditions.

Know what to watch for and get tips for reducing your risks while taking this drug.

Tacrolimus Side Effects

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • burning or tingling in the hands or feet
  • changes in vision
  • chest pain
  • fever, chills or any other sign of infection
  • increased thirst or hunger
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • seizures
  • swelling of the feet or legs, unusual or sudden weight gain
  • trouble passing urine or change in the amount of urine
  • unusual bleeding or bruising
  • unusually weak or tired
  • yellowing of skin or eyes

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • confusion
  • constipation
  • diarrhea
  • difficulty sleeping
  • headache
  • nausea
  • tremors

Tacrolimus May Interact with Other Medications

Do not take this medicine with any of the following medications:

  • astemizole
  • certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
  • cidofovir
  • cisapride
  • cyclosporine
  • dofetilide
  • dronedarone
  • droperidol
  • grepafloxacin
  • pimozide
  • probucol
  • thioridazine
  • ziprasidone

This medicine may also interact with the following medications:

  • alcohol and medicines that contain alcohol
  • amiodarone
  • antiviral medicines for HIV or AIDS
  • bromocriptine
  • certain antibiotics like aminoglycosides, chloramphenicol, clarithromycin, erythromycin, rifabutin, rifampin, troleandomycin
  • certain calcium channel blockers like diltiazem, nicardipine, nifedipine, verapamil
  • certain medicines for fungal infections like amphotericin B, caspofungin, clotrimazole
  • certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
  • certain medicines for stomach problems like antacids, cimetidine, famotidine, lansoprazole, metoclopramide, omeprazole
  • certain supplements that contain schisandra sphenanthera extracts
  • cisplatin
  • danazol
  • diuretics
  • ethinyl estradiol
  • ganciclovir
  • grapefruit juice
  • nefazodone
  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)
  • sirolimus
  • St. John's wort
  • steroid medicines like prednisone or cortisone
  • vaccines
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

How to Use tacrolimus

This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • diabetes
  • heart disease or heart failure
  • high blood pressure
  • infection
  • kidney disease
  • an unusual or allergic reaction to tacrolimus, castor oil, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

This does not apply.

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Your blood sugar may increase while you are taking this medicine. Call your doctor or health care professional for advice if you have any of the following symptoms: increased thirst, dry mouth, pass urine frequently, notice a fruity odor on your breath, or feel tired and lose your appetite.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

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