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Side Effects of Tepadina
Common side effects of Tepadina include:
- increased risk to infection
- whole-body inflammation sepsis)
- decreased counts of white blood cells, platelets and red blood cells (anaemia)
- the transplanted cells attack your body (graft versus host disease)
- dizziness, headache, blurred vision
- uncontrolled shaking of the body (convulsion)
- sensation of tingling, pricking or numbness
- partial loss of movement
- cardiac arrest
- nausea, vomiting, diarrhea
- inflammation of the mucosa of the mouth (mucositis)
- irritated stomach, gullet, intestine
- inflammation of the colon
- anorexia, decreased appetite
- high blood sugar
- skin rash, itching, shedding
- skin colour disorder
- redness of the skin
- hair loss
- back and abdominal pain
- muscle and joint pain
- inflammation of lung tissue
- enlarged liver
- altered organ function
- blocking of a liver vein (VOD)
- yellowing of the skin and eyes (jaundice)
- hearing impairment
- high blood pressure
- increased liver, renal and digestive enzymes
- abnormal blood electrolytes
- weight gain
- fever, general weakness, chills
- nasal bleeding
- general swelling due to fluid retention (oedema)
- pain or inflammation at the injection site
- eye infection (conjunctivitis)
- decreased sperm cell count
- vaginal bleeding
- absence of menstrual periods (amenorrhea)
- memory loss
- delaying in weight and height increase
- bladder disfunction
- underproduction of testosterone
- insufficient production of thyroid hormone
- deficient activity of the pituitary gland
- anxiety, confusion
- abnormal bulging outward of one of the arteries in the brain (intracranial aneurysm)
- allergic reactions
- blockage of a blood vessel (embolism)
- heart problems
- oxygen deficiency
- fluid accumulation in the lungs (pulmonary edema)
- pulmonary bleeding
- respiratory arrest
- blood in the urine (haematuria) and moderate renal insufficiency
- inflammation of the urinary bladder
- discomfort in urination and decrease in urine output (disuria and oliguria)
- increase in the amount of nitrogen components in the blood stream (BUN increase)
- inability of the liver
- cerebral haemorrhage
- constipation and upset stomach
- obstruction of the bowel
- perforation of stomach
- changes in muscle tone
- gross lack of coordination of muscle movements
- bruises due to a low platelet count
- menopausal symptoms
- cancer (second primary malignancies)
- abnormal brain function
This is not a complete list of Tepadina side effects. Ask your doctor or pharmacist for more information.
Tell your doctor if you have any side effect that bothers you or that does not go away.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Before Using Tepadina
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of thiotepa injection in children with class 3 beta-thalassemia. However, safety and efficacy of thiotepa injection to treat malignant effusions, breast, ovary, and urinary bladder cancer in children have not been established in children.
Although appropriate studies on the relationship of age to the effects of thiotepa injection have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving thiotepa injection.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Adenovirus Vaccine Type 4, Live
- Adenovirus Vaccine Type 7, Live
- Bacillus of Calmette and Guerin Vaccine, Live
- Cholera Vaccine, Live
- Influenza Virus Vaccine, Live
- Measles Virus Vaccine, Live
- Mumps Virus Vaccine, Live
- Poliovirus Vaccine, Live
- Rotavirus Vaccine, Live
- Rubella Virus Vaccine, Live
- Smallpox Vaccine
- Typhoid Vaccine
- Varicella Virus Vaccine
- Yellow Fever Vaccine
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- St John's Wort
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Bleeding problems or
- Seizures—Use with caution. May make these conditions worse.
- Infection—May decrease your body's ability to fight infection.
- Kidney disease, moderate to severe or
- Liver disease, moderate to severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Uses of Tepadina
- It is used to treat cancer.
- It is used before bone marrow or stem cell transplant.
- It may be given to you for other reasons. Talk with the doctor.
What are some other side effects of Tepadina?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Loose stools (diarrhea).
- Hair loss.
- Not hungry.
- Upset stomach or throwing up.
- Feeling tired or weak.
- Belly pain.
- Irritation where this medicine is given.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.