Trifluridine and Tipiracil

Name: Trifluridine and Tipiracil

Trifluridine and Tipiracil Overview

Trifluridine/tipiracil is a prescription medication used to treat advanced colorectal cancer. It is a single product containing trifluridine and tipiracil. 

Trifluridine belongs to a group of drugs called nucleoside metabolic inhibitor. Tipiracil belongs to a group of drugs called thymidine phosphorylase inhibitor. Together these work to stop the growth and spread of cancer cells.

It is available in tablet form and is typically taken twice a day, within 1 hour of morning and evening meals.  

Common side effects of this medication may include decrease in blood cell counts, fatigue, and nausea.

Trifluridine and Tipiracil Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of trifluridine/tipiracil, there are no specific foods that you must exclude from your diet when receiving this medication.

Other Requirements

  • Store at 20°C to 25°C (68°F to 77°F).
  • Trifluridine/tipiracil is a cytotoxic drug. Follow applicable special handling and disposal procedures.
  • Keep this and all medicines out of the reach of children.
  • If stored outside of original bottle, discard, following disposal procedures, after 30 days. 

Before Using trifluridine and tipiracil

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For trifluridine and tipiracil, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to trifluridine and tipiracil or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of Lonsurf® in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Lonsurf® in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of trifluridine and tipiracil. Make sure you tell your doctor if you have any other medical problems, especially:

  • Kidney disease, moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Brand Names U.S.

  • Lonsurf
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