Name: Tums Regular
Frequency Not Defined
Suspected digoxin toxicity
Shake suspension well; chew tablets thoroughly
Absorption impaired in achlorhydria
Hypercalcemia and hypercalciuria may result from long-term use
Advise patients to limit intake of oxalate-rich foods (soy; green, leafy vegetables; animal protein) to avoid reduced absorption through Ca-oxalate formation
Pregnancy & Lactation
Pregnancy category: C
Lactation: Safe; crosses the placenta; appears in breast milk
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Antacid: Neutralizes gastric acidity
Dietary supplement: Prevents or treats negative Ca balance; oral Ca supplements may protect against renal calculi formation by chelating with oxalate in gut and preventing its absorption
Phosphate binder: Binds with dietary phosphate to form insoluble calcium phosphate, which is excreted in feces
Bioavailability: 25-35%; food increases absorption 10-30%; antacid action dependent on gastric emptying time
Peak plasma time: 20-60 min (fasting state); up to 3 hr (ingested 1 hr after meals)
Protein bound: 45%
Renal clearance: 50-300 mg/day
Excretion: Feces, as unabsorbed calcium (80%); urine (20%)